MDM2 is upregulated in PDAC tissues and correlates with clinicopathological characteristics
D. Zhu, et al. Cancer Letters 477 (2020) 107–121 Fig. 3. MDM2 is upregulated in PDAC tissues and correlates with clinicopathological characteristics, and dysbindin expression is positively correlated withMDM2expressioninPDACtissues.(A)WesternblotanalysisshowingMDM2proteinlevelsinPDACtissues(n=8)andpairedadjacentnoncanceroustissues. Thedataarepresentedasthemean ± SEM.(B)qRT-PCRanalysisshowingMDM2mRNAlevelsinPDACtissues(n=8)andpairedadjacentnoncanceroustissues. Thedataarepresentedasthemean ± SEM.(C)MDM2expressionwasdetectedonatissuemicroarraycontaining63PDACspecimensand57adjacentnoncancerous tissues.RepresentativeIHCstainingprofilesofMDM2indifferentgroupsareshown.ANT,adjacentnoncanceroustissue;T,tumourtissue.Scalebars:top,200μm; bottom,50μm.(D)MDM2expressionlevelsin63PDACtissuesand57adjacentnoncanceroustissueswereanalysedbyPearson\'schi-squaretest.(E)Analysisofthe IHC scores for MDM2 in PDAC tissues and adjacent noncancerous tissues. ANT, adjacent noncancerou...